CYP3A4 intronic SNP rs35599367 (CYP3A4*22) alters RNA splicing
نویسندگان
چکیده
منابع مشابه
Alternative splicing due to an intronic SNP in HMSD generates a novel minor histocompatibility antigen.
Here we report the identification of a novel human leukocyte antigen (HLA)-B44-restricted minor histocompatibility antigen (mHA) with expression limited to hematopoietic cells. cDNA expression cloning studies demonstrated that the cytotoxic T lymphocyte (CTL) epitope of interest was encoded by a novel allelic splice variant of HMSD, hereafter designated as HMSD-v. The immunogenicity of the epit...
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RNA splicing, a post-transcriptional process necessary to form a mature mRNA, was discovered in the late 1970s. Two different modes of splicing have been defined, that is, constitutive splicing and alternative splicing. Constitutive splicing is the process of removing introns from the premRNA, and joining the exons together to form a mature mRNA. Alternative splicing, on the other hand, is the ...
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ژورنال
عنوان ژورنال: Pharmacogenetics and Genomics
سال: 2016
ISSN: 1744-6872
DOI: 10.1097/fpc.0000000000000183